A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups.

ABSTRACT:

Introduction

Existing blood-based biomarkers for Alzheimer's disease (AD) mainly focus on its pathological features. However, studies on blood-based biomarkers associated with other biological processes for a comprehensive evaluation of AD status are limited.

Methods

We developed a blood-based, multiplex biomarker assay for AD that measures the levels of 21 proteins involved in multiple biological pathways. We evaluated the assay's performance for classifying AD and indicating AD-related endophenotypes in three independent cohorts from Chinese or European-descent populations.

Results

The 21-protein assay accurately classified AD (area under the receiver operating characteristic curve [AUC] = 0.9407 to 0.9867) and mild cognitive impairment (MCI; AUC = 0.8434 to 0.8945)

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC10984431 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature