Comparison of plasma biomarkers and amyloid PET for predicting memory decline in cognitively unimpaired individuals.

ABSTRACT:

Background

We compared the ability of several plasma biomarkers versus amyloid positron emission tomography (PET) to predict rates of memory decline among cognitively unimpaired individuals.

Methods

We studied 645 Mayo Clinic Study of Aging participants. Predictor variables were age, sex, education, apolipoprotein E (APOE) ε4 genotype, amyloid PET, and plasma amyloid beta (Aβ)42/40, phosphorylated tau (p-tau)181, neurofilament light (NfL), glial fibrillary acidic protein (GFAP), and p-tau217. The outcome was a change in a memory composite measure.

Results

All plasma biomarkers, except NfL, were associated with mean memory decline in models with individual biomarkers. However, amyloid PET and plasma p-tau217, along with age, were key variables independently associated

SUBMITTER: Jack CR 

PROVIDER: S-EPMC10984437 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature