Predictors and outcomes of fluctuations in the clinical dementia rating scale.

ABSTRACT:

Introduction

Reversion, or change in cognitive status from impaired to normal, is common in aging and dementia studies, but it remains unclear what factors predict reversion.

Methods

We investigated whether reverters, defined as those who revert from a Clinical Dementia Rating® (CDR®) scale score of 0.5 to CDR 0) differed on cognition and biomarkers from unimpaired participants (always CDR 0) and impaired participants (converted to CDR > 0 and had no reversion events). Models evaluated relationships between biomarker status, apolipoprotein E (APOE) ε4 status, and cognition. Additional models described predictors of reversion and predictors of eventual progression to CDR > 0.

Results

CDR reversion was associated with younger age, better cognition, and negative amyloid

SUBMITTER: Wilks H 

PROVIDER: S-EPMC10984446 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature