Predicting clinical progression trajectories of early Alzheimer's disease patients.

ABSTRACT:

Background

Models for forecasting individual clinical progression trajectories in early Alzheimer's disease (AD) are needed for optimizing clinical studies and patient monitoring.

Methods

Prediction models were constructed using a clinical trial training cohort (TC; n = 934) via a gradient boosting algorithm and then evaluated in two validation cohorts (VC 1, n = 235; VC 2, n = 421). Model inputs included baseline clinical features (cognitive function assessments, APOE ε4 status, and demographics) and brain magnetic resonance imaging (MRI) measures.

Results

The model using clinical features achieved R² of 0.21 and 0.31 for predicting 2-year cognitive decline in VC 1 and VC 2, respectively. Adding MRI features improved the R² to 0.29 in VC 1, whic

SUBMITTER: Devanarayan V 

PROVIDER: S-EPMC10984448 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature