Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging.

ABSTRACT:

Introduction

We examined the association of clinical, microbiological, and host response features of periodontitis with MRI markers of atrophy/cerebrovascular disease in the Washington Heights Inwood Columbia Aging Project (WHICAP) Ancillary Study of Oral Health.

Methods

We analyzed 468 participants with clinical periodontal data, microbial plaque and serum samples, and brain MRIs. We tested the association of periodontitis features with MRI features, after adjusting for multiple risk factors for Alzheimer's disease/Alzheimer's disease-related dementia (AD/ADRD).

Results

In fully adjusted models, having more teeth was associated with lower odds for infarcts, lower white matter hyperintensity (WMH) volume, higher entorhinal cortex volume, and higher cortical thickness.

SUBMITTER: Rubinstein T 

PROVIDER: S-EPMC10984451 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature