Blood-based biomarkers for Alzheimer's disease and cognitive function from mid- to late life.

ABSTRACT:

Introduction

We investigated associations of Alzheimer's disease (AD) serum biomarkers with longitudinal changes in cognitive function from mid- to late life among women.

Methods

The study population included 192 women with the median age of 53.3 years at baseline, from the Study of Women's Health Across the Nation Michigan Cohort, followed up over 14 years. Associations between baseline serum amyloid β (Aβ)42, the Aβ42/40 ratio, phosphorylated tau181 (p-tau181), and total tau with longitudinal changes in cognition were evaluated using linear mixed effects models.

Results

After adjusting for confounders, lower Aβ42/40 ratios were associated with faster declines in the Digit Span Backward Test. Higher p-tau181 also showed a borderline statistically significant associat

SUBMITTER: Wang X 

PROVIDER: S-EPMC10984504 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature