Association of per- and polyfluoroalkyl substances with constipation: The National Health and Nutrition Examination Survey (2005-2010).

ABSTRACT:

Background

The impact of per- and polyfluoroalkyl substances (PFAS) on constipation, as mediated through gastrointestinal absorption and perturbations to the intestinal microecology, remains poorly understood.

Objective

This study seeks to explain the relationship between PFAS and constipation.

Methods

A total of 2945 adults from the National Health and Nutrition Examination Survey (NHANES) 2005-2010 were included in this study. Constipation was defined using the Bristol Stool Form Scale (BSFS) based on stool consistency. The relationship between PFAS and constipation was evaluated using weighted logistic regression and restricted cubic spline (RCS) analysis, while adjusting for confounding variables.

Results

The weighted median concentration of total PFAS (ΣPF

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10984548 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature