Transcatheter or surgical aortic valve implantation: 10-year outcomes of the NOTION trial.

ABSTRACT:

Background and aims

Transcatheter aortic valve implantation (TAVI) has become a viable treatment option for patients with severe aortic valve stenosis across a broad range of surgical risk. The Nordic Aortic Valve Intervention (NOTION) trial was the first to randomize patients at lower surgical risk to TAVI or surgical aortic valve replacement (SAVR). The aim of the present study was to report clinical and bioprosthesis outcomes after 10 years.

Methods

The NOTION trial randomized 280 patients to TAVI with the self-expanding CoreValve (Medtronic Inc.) bioprosthesis (n = 145) or SAVR with a bioprosthesis (n = 135). The primary composite outcome was the risk of all-cause mortality, stroke, or myocardial infarction. Bioprosthetic valve dysfunction (BVD) was classified as structu

SUBMITTER: Thyregod HGH 

PROVIDER: S-EPMC10984572 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature