Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability.

ABSTRACT:

Objective

The authors investigated the neural impact of intranasal oxytocin on emotion processing areas in youths with severe irritability in the context of disruptive mood and behavior disorders.

Methods

Fifty-two participants with severe irritability, as measured by a score ≥4 on the Affective Reactivity Index (ARI), with diagnoses of disruptive behavior disorders (DBDs) and/or disruptive mood dysregulation disorder (DMDD) were randomly assigned to treatment with intranasal oxytocin or placebo daily for 3 weeks. Assessments were conducted at baseline and at the end of the trial; the primary outcomes were measures of irritability on the ARI and ratings on the Clinical Global Impressions severity scale (CGI-S) focusing on DBD and DMDD symptoms, and secondary outcomes include

SUBMITTER: Hwang S 

PROVIDER: S-EPMC10984767 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature