Aging and the emerging role of cellular senescence in osteoarthritis.

ABSTRACT:

Objective

The correlation between age and incidence of osteoarthritis (OA) is well known but the causal mechanisms involved are not completely understood. This narrative review summarizes selected key findings from the past 30 years that have elucidated key aspects of the relationship between aging and OA.

Methods

The peer-reviewed English language literature was searched on PubMed using keywords including senescence, aging, cartilage, and osteoarthritis, for original studies and reviews published from 1993 to 2023 with a major focus on more recent studies. Manuscripts most relevant to aging and OA that examined one or more of the hallmarks of aging were selected for further review.

Results

All proposed hallmarks of aging have been observed in articular cartilage and

SUBMITTER: Diekman BO 

PROVIDER: S-EPMC10984800 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature