Discordant gene expression in subcutaneous adipose and skeletal muscle tissues in response to exercise training.

ABSTRACT: Exercise has different effects on different tissues in the body, the sum of which may determine the response to exercise and the health benefits. In the present study, we aimed to investigate whether physical training regulates transcriptional network communites common to both skeletal muscle (SM) and subcutaneous adipose tissue (SAT). Eight such shared transcriptional communities were found in both tissues. Eighteen young overweight adults voluntarily participated in 7 weeks of combined strength and endurance training (five training sessions per week). Biopsies were taken from SM and SAT before and after training. Five of the network communities were regulated by training in SM but showed no change in SAT. One community involved in insulin- AMPK signaling and glucose utilization was upreg

SUBMITTER: Svensson M 

PROVIDER: S-EPMC10984804 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature