Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis.

ABSTRACT: Both EphB2- and EphB3-deficient mice exhibit profound histological alterations in the thymic epithelial network but few changes in T-cell differentiation, suggesting that this organization would be sufficient to produce functional T lymphocytes. Also, other antigen-presenting cells involved in immunological education could substitute the thymic epithelium. Accordingly, we found an increased frequency of plasmacytoid dendritic cells but not of conventional dendritic cells, medullary fibroblasts or intrathymic B lymphocytes. In addition, there are no lymphoid infiltrates in the organs of mutant mice nor do they contain circulating autoantibodies. Furthermore, attempts to induce arthritic lesions after chicken type II collagen administration fail totally in EphB2-deficient mice whereas all WT

SUBMITTER: Montero-Herradon S 

PROVIDER: S-EPMC10984909 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature