Identification and evolution of ICE-PmuST394: a novel integrative conjugative element in Pasteurella multocida ST394.

ABSTRACT:

Background

The emergence of macrolide and tetracycline resistance within Pasteurella multocida isolated from feedlot cattle and the dominance of ST394 in Australia was reported recently.

Objectives

To establish the genetic context of the resistance genes in P. multocida 17BRD-035, the ST394 reference genome, and conduct a molecular risk assessment of their ability to disperse laterally.

Methods

A bioinformatic analysis of the P. multocida 17BRD-035 genome was conducted to determine if integrative conjugative elements (ICEs) carrying resistance genes, which hamper antibiotic treatment options locally, are in circulation in Australian feedlots.

Results

A novel element, ICE-PmuST394, was characterized in P. multocida 17BRD-035. It was also identified in three othe

SUBMITTER: Roy Chowdhury P 

PROVIDER: S-EPMC10984947 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature