Automated and miniaturized screening of antibiotic combinations via robotic-printed combinatorial droplet platform.

ABSTRACT: Antimicrobial resistance (AMR) has become a global health crisis in need of novel solutions. To this end, antibiotic combination therapies, which combine multiple antibiotics for treatment, have attracted significant attention as a potential approach for combating AMR. To facilitate advances in antibiotic combination therapies, most notably in investigating antibiotic interactions and identifying synergistic antibiotic combinations however, there remains a need for automated high-throughput platforms that can create and examine antibiotic combinations on-demand, at scale, and with minimal reagent consumption. To address these challenges, we have developed a Robotic-Printed Combinatorial Droplet (RoboDrop) platform by integrating a programmable droplet microfluidic device that generates ant

SUBMITTER: Shao F 

PROVIDER: S-EPMC10985126 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature