Design, synthesis, and evaluation of the novel ozagrel-paeonol codrug with antiplatelet aggregation activities as a potent anti-stroke therapeutic agent.

ABSTRACT: Introduction: Ischemic stroke is the second most common chronic disease worldwide and is associated with high morbidity and mortality. Thromboembolism and platelet aggregation are the most characteristic features of stroke. Other than aspirin, no standard, accepted, or effective treatment for acute ischemic stroke has been established. Consequently, it is essential to identify novel therapeutic compounds for this condition. Methods: In this study, novel ozagrel/paeonol-containing codrugs were synthesized and characterized using ¹H-NMR, ¹³C-NMR, and mass spectroscopy. Their antiplatelet aggregation activity was evaluated, with compound PNC₃ found to exhibit the best effect. Subsequently, studies were conducted to assess its neuroprotective effe

SUBMITTER: Zuo C 

PROVIDER: S-EPMC10985144 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature