The transcription factor <i>Pou4f3</i> is essential for the survival of postnatal and adult mouse cochlear hair cells and normal hearing.

ABSTRACT:

Introduction

Hair cells (HCs) of the cochlea are responsible for sound transduction and hearing perception in mammals. Genetic mutations in the transcription factor Pou4f3 cause non-syndromic autosomal dominant hearing loss in humans (DFNA15) which varies in the age of onset depending on the individual mutation. Mouse models with germline deletion or mutations in Pou4f3 have previously demonstrated its critical role in the maturation and survival of cochlear HCs during embryonic development. However, the role of Pou4f3 in auditory function and in the survival or maintenance of cochlear HCs after birth and during adulthood has not been studied.

Methods

Therefore, using the inducible CreER-loxP system, we deleted Pou4f3 from mouse cochlear HCs at di

SUBMITTER: Singh J 

PROVIDER: S-EPMC10985149 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature