Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties.

ABSTRACT:

Introduction

Prior to pregnancy, hormonal changes lead to cellular adaptations in the endometrium allowing for embryo implantation. Critical for successful pregnancy establishment, innate immune cells constitute a significant proportion of uterine cells prior to arrival of the embryo and throughout the first trimester in humans and animal models. Abnormal uterine immune cell function during implantation is believed to play a role in multiple adverse pregnancy outcomes. Current work in humans has focused on uterine immune cells present after pregnancy establishment, and limited in vitro models exist to explore unique functions of these cells.

Methods

With single-cell RNA-sequencing (scRNAseq), we comprehensively compared the human uterine immune landscape of the endometrium d

SUBMITTER: Mani S 

PROVIDER: S-EPMC10985329 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature