Murine IRF8 Mutation Offers New Insight into Osteoclast and Root Resorption.

ABSTRACT: Interferon regulatory factor 8 (IRF8), a transcription factor expressed in immune cells, functions as a negative regulator of osteoclasts and helps maintain dental and skeletal homeostasis. Previously, we reported that a novel mutation in the IRF8 gene increases susceptibility to multiple idiopathic cervical root resorption (MICRR), a form of tooth root resorption mediated by increased osteoclast activity. The IRF8 G388S variant in the highly conserved C-terminal motif is predicted to alter the protein structure, likely impairing IRF8 function. To investigate the molecular basis of MICRR and IRF8 function in osteoclastogenesis, we generated Irf8 knock-in (KI) mice using CRISPR/Cas9 technique modeling the human IRF8^G388S mutation. The heterozygo

SUBMITTER: Das A 

PROVIDER: S-EPMC10985390 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature