Tumor Burden Dictates the Neoantigen Features Required to Generate an Effective Cancer Vaccine.

ABSTRACT: Tumor neoantigens (nAg) represent a promising target for cancer immunotherapy. The identification of nAgs that can generate T-cell responses and have therapeutic activity has been challenging. Here, we sought to unravel the features of nAgs required to induce tumor rejection. We selected clinically validated Great Ape-derived adenoviral vectors (GAd) as a nAg delivery system for differing numbers and combinations of nAgs. We assessed their immunogenicity and efficacy in murine models of low to high disease burden, comparing multi-epitope versus mono-epitope vaccines. We demonstrated that the breadth of immune response is critical for vaccine efficacy and having multiple immunogenic nAgs encoded in a single vaccine improves efficacy. The contribution of each single neoantigen was examined,

SUBMITTER: Garzia I 

PROVIDER: S-EPMC10985473 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature