Association of Fetal Catecholamines With Neonatal Hypoglycemia.

ABSTRACT:

Importance

Perinatal stress and fetal growth restriction increase the risk of neonatal hypoglycemia. The underlying pathomechanism is poorly understood. In a sheep model, elevated catecholamine concentrations were found to suppress intrauterine insulin secretion, followed by hyperresponsive insulin secretion once the adrenergic stimulus subsided.

Objective

To determine whether neonates with risk factors for hypoglycemia have higher catecholamine concentrations in umbilical cord blood (UCB) and/or amniotic fluid (AF) and whether catecholamines are correlated with postnatal glycemia.

Design, setting, and participants

In a prospective cohort study of 328 neonates at a tertiary perinatal center from September 2020 through May 2022 in which AF and UCB were collected immedi

SUBMITTER: Hoermann H 

PROVIDER: S-EPMC10985628 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature