Physical and Chemical Compatibility of Medications Commonly Used in Critically Ill Patients With Balanced Crystalloids: A Systematic Review.

ABSTRACT:

Objective

Evaluate available evidence of physical and/or chemical compatibility of commonly used medications in critically ill patients with balanced crystalloids.

Data sources

Ovid MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews were queried from inception to September 2022.

Study selection and data extraction

This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. English-language studies reporting physical and/or chemical compatibility data between 50 selected medications and balanced crystalloids were included. A previously designed tool to assess risk of bias was adapted for use.

Data synthesis

Twenty-nine studies encompassin

SUBMITTER: Buckley CT 

PROVIDER: S-EPMC10985788 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature