Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study.

ABSTRACT:

Background

Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal. Although various MPB-associated genetic variants have been suggested, a comprehensive study for linking these variants to gene expression regulation has not been performed to the best of our knowledge.

Results

In this study, we prioritized MPB-related tissue panels using tissue-specific enrichment analysis and utilized single-tissue panels from genotype-tissue expression version 8, as well as cross-tissue panels from context-specific genetics. Through a transcriptome-wide association study and colocalization analysis, we identified 52, 75, and 144 MPB associations for

SUBMITTER: Choi E 

PROVIDER: S-EPMC10985920 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature