Sialyl-Tn serves as a potential therapeutic target for ovarian cancer.

ABSTRACT:

Background

Ovarian cancer remains the deadliest of the gynecologic cancers in the United States. There have been limited advances in treatment strategies that have seen marked increases in overall survival. Thus, it is essential to continue developing and validating new treatment strategies and markers to identify patients who would benefit from the new strategy. In this report, we sought to further validate applications for a novel humanized anti-Sialyl Tn antibody-drug conjugate (anti-STn-ADC) in ovarian cancer.

Methods

We aimed to further test a humanized anti-STn-ADC in sialyl-Tn (STn) positive and negative ovarian cancer cell line, patient-derived organoid (PDO), and patient-derived xenograft (PDX) models. Furthermore, we sought to determine whether serum STn levels wou

SUBMITTER: Al-Alem L 

PROVIDER: S-EPMC10985924 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature