Critical period of oxygen supplementation and invasive ventilation: implications for severe retinopathy of prematurity.

ABSTRACT:

Background

Several studies have identified graded oxygen saturation targets to prevent retinopathy of prematurity (ROP), a serious complication in preterm infants. We aimed to analyze the critical period of oxygen supplementation and/or invasive ventilation associated with severe ROP.

Methods

This retrospective case-control study included neonates with a gestational age (GA) < 29 weeks. Participants were divided into two groups: treated retinopathy and untreated/no retinopathy. Time-weighted average FiO₂ (TWAFiO₂) and weekly invasive ventilation were compared between groups by postnatal age (PNA) and postmenstrual age (PMA). The association of treated retinopathy with TWAFiO₂ and invasive ventilation was analyzed.

Results

Data from 287

SUBMITTER: Choi HJ 

PROVIDER: S-EPMC10985977 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature