Blood leukocytes as a non-invasive diagnostic tool for thyroid nodules: a prospective cohort study.

ABSTRACT:

Background

Thyroid nodule (TN) patients in China are subject to overdiagnosis and overtreatment. The implementation of existing technologies such as thyroid ultrasonography has indeed contributed to the improved diagnostic accuracy of TNs. However, a significant issue persists, where many patients undergo unnecessary biopsies, and patients with malignant thyroid nodules (MTNs) are advised to undergo surgery therapy.

Methods

This study included a total of 293 patients diagnosed with TNs. Differential methylation haplotype blocks (MHBs) in blood leukocytes between MTNs and benign thyroid nodules (BTNs) were detected using reduced representation bisulfite sequencing (RRBS). Subsequently, an artificial intelligence blood leukocyte DNA methylation (BLDM) model was designed to opt

SUBMITTER: Wang F 

PROVIDER: S-EPMC10986011 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature