MFGE8 in exosomes derived from mesenchymal stem cells prevents esophageal stricture after endoscopic submucosal dissection in pigs.

ABSTRACT:

Background

Endoscopic submucosal dissection (ESD) is the current standard treatment for early-stage esophageal neoplasms. However, the postoperative esophageal stricture after extensive mucosal dissection remains a severe challenge with limited effective treatments available. In this study, we introduced a chitosan/gelatin (ChGel) sponge encapsulating the adipose mesenchymal stem cells (ADMSCs)-derived exosomes (ChGel^MSC-Exo) for the prevention of esophageal stenosis after ESD in a porcine model.

Results

Pigs were randomly assigned into (1) ChGel^MSC-Exo treatment group, (2) ChGel^PBS group, and (3) the controls. Exosome treatments were applied immediately on the day after ESD as well as on day 7. Exosome components crucial for wound healing we

SUBMITTER: Lai H 

PROVIDER: S-EPMC10986023 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature