Transcriptional dynamics during Rhodococcus erythropolis infection with phage WC1.

ABSTRACT:

Background

Belonging to the Actinobacteria phylum, members of the Rhodococcus genus thrive in soil, water, and even intracellularly. While most species are non-pathogenic, several cause respiratory disease in animals and, more rarely, in humans. Over 100 phages that infect Rhodococcus species have been isolated but despite their importance for Rhodococcus ecology and biotechnology applications, little is known regarding the molecular genetic interactions between phage and host during infection. To address this need, we report RNA-Seq analysis of a novel Rhodococcus erythopolis phage, WC1, analyzing both the phage and host transcriptome at various stages throughout the infection process.

Results

By five minutes post-infection WC1 showed upregulation of a CAS-4 family exonucle

SUBMITTER: Willner DL 

PROVIDER: S-EPMC10986025 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature