Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies.

ABSTRACT: Cancer stem cells (CSCs) were first discovered in the 1990s, revealing the mysteries of cancer origin, migration, recurrence and drug-resistance from a new perspective. The expression of pluripotent genes and complex signal regulatory networks are significant features of CSC, also act as core factors to affect the characteristics of CSC. Transcription is a necessary link to regulate the phenotype and potential of CSC, involving chromatin environment, nucleosome occupancy, histone modification, transcription factor (TF) availability and cis-regulatory elements, which suffer from ambient pressure. Especially, the expression and activity of pluripotent TFs are deeply affected by both internal and external factors, which is the foundation of CSC transcriptional regulation in the current resear

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10986082 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature