TRAF6-mediated ubiquitination of AKT in the nucleus is a critical event underlying the desensitization of G protein-coupled receptors.

ABSTRACT:

Background

Desensitization of G protein-coupled receptors (GPCRs) refers to the attenuation of receptor responsiveness by prolonged or intermittent exposure to agonists. The binding of β-arrestin to the cytoplasmic cavity of the phosphorylated receptor, which competes with the G protein, has been widely accepted as an extensive model for explaining GPCRs desensitization. However, studies on various GPCRs, including dopamine D₂-like receptors (D₂R, D₃R, D₄R), have suggested the existence of other desensitization mechanisms. The present study employed D₂R/D₃R variants with different desensitization properties and utilized loss-of-function approaches to uncover the mechanisms underlying GPCRs homologous desensitization,

SUBMITTER: Wu C 

PROVIDER: S-EPMC10986131 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature