Immune cell infiltration and drug response in glioblastoma multiforme: insights from oxidative stress-related genes.

ABSTRACT:

Background

GBM, also known as glioblastoma multiforme, is the most prevalent and lethal type of brain cancer. The cell proliferation, invasion, angiogenesis, and treatment of gliomas are significantly influenced by oxidative stress. Nevertheless, the connection between ORGs and GBM remains poorly comprehended. The objective of this research is to investigate the predictive significance of ORGs in GBM and their potential as targets for therapy.

Methods

We identified differentially expressed genes in glioma and ORGs from public databases. A risk model was established using LASSO regression and Cox analysis, and its performance was evaluated with ROC curves. We then performed consistent cluster analysis on the model, examining its correlation with immunity and drug response. Ad

SUBMITTER: Wang K 

PROVIDER: S-EPMC10986133 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature