Ketamine improves neuronal recovery following spreading depolarization in peri-infarct tissues.

ABSTRACT: Spreading depolarization (SD) has emerged as an important contributor to the enlargement of acute brain injuries. We previously showed that the N-methyl-D-aspartate receptor antagonist ketamine was able to prevent deleterious consequences of SD in brain slices, under conditions of metabolic compromise. The current study aimed to extend these observations into an in vivo stroke model, to test whether gradients of metabolic capacity lead to differential accumulation of calcium (Ca²⁺) following SD. In addition, we tested whether ketamine protects vulnerable tissuewhile allowing SD to propagate through surrounding undamaged tissue. Focal lesions were generated using a distal middle cerebral artery occlusion in mice, and clusters of SD were generated at 20 min intervals with remote m

SUBMITTER: Reinhart KM 

PROVIDER: S-EPMC10986311 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature