Lung microbiota composition, respiratory mechanics, and outcomes in COVID-19-related ARDS.

ABSTRACT: Few data are available on the lung microbiota composition of patients with coronavirus disease 2019-related acute respiratory distress syndrome (C-ARDS) receiving invasive mechanical ventilation (IMV). Moreover, it has never been investigated whether there is a potential correlation between lung microbiota communities and respiratory mechanics. We performed a prospective observational study in two intensive care units of a university hospital in Italy. Lung microbiota was investigated by bacterial 16S rRNA gene sequencing, performed on bronchoalveolar lavage fluid samples withdrawn after intubation. The lung bacterial communities were analyzed after stratification by respiratory system compliance/predicted body weight (Crs) and ventilatory ratio (VR). Weaning from IMV and hospital survival

SUBMITTER: De Pascale G 

PROVIDER: S-EPMC10986322 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature