Pathogenomic analysis and characterization of Pasteurella multocida strains recovered from human infections.

ABSTRACT: Pasteurella multocida is an upper respiratory tract commensal in several mammal and bird species but can also cause severe disease in humans and in production animals such as poultry, cattle, and pigs. In this study, we performed whole-genome sequencing of P. multocida isolates recovered from a range of human infections, from the mouths of cats, and from wounds on dogs. Together with publicly available P. multocida genome sequences, we performed phylogenetic and comparative genomic analyses. While isolates from cats and dogs were spread across the phylogenetic tree, human infections were caused almost exclusively by subsp. septica strains. Most of the human isolates were capsule type A and LPS type L1 and L3; however, some strains lacked a capsule biosynthesis l

SUBMITTER: Smallman TR 

PROVIDER: S-EPMC10986470 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature