The injured monocyte: The link to chronic critical illness and mortality following injury.

ABSTRACT:

Background

This study aimed to understand the altered innate immune response in severely injured patients leading to chronic critical illness (CCI). Specifically, it focused on characterizing the monocyte populations and their correlation with CCI development and long-term complications.

Methods

Over a 3-year period, we monitored patients with severe injuries for up to 1-year postinjury. Chronic critical illness was defined as an ICU stay exceeding 14 days with persistent organ failure. Blood samples were collected on Days 1 and 5 for monocyte phenotypic expression analysis using cytometry by time flight. The monocyte subpopulations studied were classical (CL), intermediate (INT), and nonclassical (NC), along with cell surface receptor expression and activation.

Results</

SUBMITTER: Cuschieri J 

PROVIDER: S-EPMC10986485 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature