Gut Microbiota and Blood Metabolites Related to Fiber Intake and Type 2 Diabetes.

ABSTRACT:

Background

Consistent evidence suggests diabetes-protective effects of dietary fiber intake. However, the underlying mechanisms, particularly the role of gut microbiota and host circulating metabolites, are not fully understood. We aimed to investigate gut microbiota and circulating metabolites associated with dietary fiber intake and their relationships with type 2 diabetes (T2D).

Methods

This study included up to 11 394 participants from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos). Diet was assessed with two 24-hour dietary recalls at baseline. We examined associations of dietary fiber intake with gut microbiome measured by shotgun metagenomics (350 species/85 genera and 1958 enzymes; n=2992 at visit 2), serum metabolome measured by untargeted metabolom

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10987058 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature