Disrupting abnormal neuronal oscillations with adaptive delayed feedback control.

ABSTRACT: Closed-loop neuronal stimulation has a strong therapeutic potential for neurological disorders such as Parkinson's disease. However, at the moment, standard stimulation protocols rely on continuous open-loop stimulation and the design of adaptive controllers is an active field of research. Delayed feedback control (DFC), a popular method used to control chaotic systems, has been proposed as a closed-loop technique for desynchronisation of neuronal populations but, so far, was only tested in computational studies. We implement DFC for the first time in neuronal populations and access its efficacy in disrupting unwanted neuronal oscillations. To analyse in detail the performance of this activity control algorithm, we used specialised in vitro platforms with high spatiotemporal monitoring/sti

SUBMITTER: Leite de Castro D 

PROVIDER: S-EPMC10987087 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature