NanoSHP099-Targeted SHP2 Inhibition Boosts Ly6C^low Monocytes/Macrophages Differentiation to Accelerate Thrombolysis.

ABSTRACT: Tumor-associated thrombus (TAT) accounts for a high proportion of venous thromboembolism. Traditional thrombolysis and anticoagulation methods are not effective due to various complications and contraindications, which can easily lead to patients dying from TAT rather than the tumor itself. These clinical issues demonstrate the need to research diverse pathways for adjuvant thrombolysis in antitumor therapy. Previously, the phenotypic and functional transformation of monocytes/macrophages is widely reported to be involved in intratribal collagen regulation. This study finds that myeloid deficiency of the oncogene SHP2 sensitizes Ly6C^low monocyte/macrophage differentiation and can alleviate thrombus organization by increasing thrombolytic Matrix metalloproteinase (MMP) 2/9 activi

SUBMITTER: Ying K 

PROVIDER: S-EPMC10987109 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature