M⁶A Methylated Long Noncoding RNA LOC339803 Regulates Intestinal Inflammatory Response.

ABSTRACT: Cytokine mediated sustained inflammation increases the risk to develop different complex chronic inflammatory diseases, but the implicated mechanisms remain unclear. Increasing evidence shows that long noncoding RNAs (lncRNAs) play key roles in the pathogenesis of inflammatory disorders, while inflammation associated variants are described to affect their function or essential RNA modifications as N⁶-methyladenosine (m⁶A) methylation, increasing predisposition to inflammatory diseases. Here, the functional implication of the intestinal inflammation associated lncRNA LOC339803 in the production of cytokines by intestinal epithelial cells is described. Allele-specific m⁶A methylation is found to affect YTHDC1 mediated protein binding affinity. LOC339803-YTHDC

SUBMITTER: Olazagoitia-Garmendia A 

PROVIDER: S-EPMC10987157 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature