Transmembrane pH gradient imaging in rodent glioma models.

ABSTRACT: A unique feature of the tumor microenvironment is extracellular acidosis in relation to intracellular milieu. Metabolic reprogramming in tumors results in overproduction of H⁺ ions (and lactate), which are extruded from the cells to support tumor survival and progression. As a result, the transmembrane pH gradient (ΔpH), representing the difference between intracellular pH (pH_i) and extracellular pH (pH_e), is posited to be larger in tumors compared with normal tissue. Controlling the transmembrane pH difference has promise as a potential therapeutic target in cancer as it plays an important role in regulating drug delivery into cells. The current study shows successful development of an MRI/MRSI-based technique that provides ΔpH imaging at submillimeter res

SUBMITTER: Mishra SK 

PROVIDER: S-EPMC10987279 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature