Expression of influenza A virus glycan receptor candidates in mallard, chicken, and tufted duck.

ABSTRACT: Influenza A virus (IAV) pandemics result from interspecies transmission events within the avian reservoir and further into mammals including humans. Receptor incompatibility due to differently expressed glycan structures between species has been suggested to limit zoonotic IAV transmission from the wild bird reservoir as well as between different bird species. Using glycoproteomics, we have studied the repertoires of expressed glycan structures with focus on putative sialic acid-containing glycan receptors for IAV in mallard, chicken and tufted duck; three bird species with different roles in the zoonotic ecology of IAV. The methodology used pinpoints specific glycan structures to specific glycosylation sites of identified glycoproteins and was also used to successfully discriminate α2-3-

SUBMITTER: Nilsson J 

PROVIDER: S-EPMC10987293 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature