Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk.

ABSTRACT: Obesity is a well-established risk factor for human cancer, yet the underlying mechanisms remain elusive. Immune dysfunction is commonly associated with obesity but whether compromised immune surveillance contributes to cancer susceptibility in individuals with obesity is unclear. Here we use a mouse model of diet-induced obesity to investigate tumor-infiltrating CD8 ⁺ T cell responses in lean, obese, and previously obese hosts that lost weight through either dietary restriction or treatment with semaglutide. While both strategies reduce body mass, only dietary intervention restores T cell function and improves responses to immunotherapy. In mice exposed to a chemical carcinogen, obesity-related immune dysfunction leads to higher incidence of sarcoma development. However, impair

SUBMITTER: Piening A 

PROVIDER: S-EPMC10987624 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature