Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections.

ABSTRACT:

Background

Self-sampling of dried blood spots (DBS) offers new routes to gather valuable health-related information from the general population. Yet, the utility of using deep proteome profiling from home-sampled DBS to obtain clinically relevant insights about SARS-CoV-2 infections remains largely unexplored.

Methods

Our study involved 228 individuals from the general Swedish population who used a volumetric DBS sampling device and completed questionnaires at home during spring 2020 and summer 2021. Using multi-analyte COVID-19 serology, we stratified the donors by their response phenotypes, divided them into three study sets, and analyzed 276 proteins by proximity extension assays (PEA). After normalizing the data to account for variances in layman-collected samples, we in

SUBMITTER: Fredolini C 

PROVIDER: S-EPMC10987641 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature