Diallel panel reveals a significant impact of low-frequency genetic variants on gene expression variation in yeast.

ABSTRACT: Unraveling the genetic sources of gene expression variation is essential to better understand the origins of phenotypic diversity in natural populations. Genome-wide association studies identified thousands of variants involved in gene expression variation, however, variants detected only explain part of the heritability. In fact, variants such as low-frequency and structural variants (SVs) are poorly captured in association studies. To assess the impact of these variants on gene expression variation, we explored a half-diallel panel composed of 323 hybrids originated from pairwise crosses of 26 natural Saccharomyces cerevisiae isolates. Using short- and long-read sequencing strategies, we established an exhaustive catalog of single nucleotide polymorphisms (SNPs) and SVs for this panel. C

SUBMITTER: Tsouris A 

PROVIDER: S-EPMC10987670 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature