Leaky gut, circulating immune complexes, arthralgia, and arthritis in IBD: coincidence or inevitability?

ABSTRACT: Most host-microbiota interactions occur within the intestinal barrier, which is essential for separating the intestinal epithelium from toxins, microorganisms, and antigens in the gut lumen. Gut inflammation allows pathogenic bacteria to enter the blood stream, forming immune complexes which may deposit on organs. Despite increased circulating immune complexes (CICs) in patients with inflammatory bowel disease (IBD) and discussions among IBD experts regarding their potential pathogenic role in extra-intestinal manifestations, this phenomenon is overlooked because definitive evidence demonstrating CIC-induced extra-intestinal manifestations in IBD animal models is lacking. However, clinical observations of elevated CICs in newly diagnosed, untreated patients with IBD have reignited research

SUBMITTER: Jin XY 

PROVIDER: S-EPMC10987687 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature