T cell dysfunction in elderly ARDS patients based on miRNA and mRNA integration analysis.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is respiratory failure that commonly occurs in critically ill patients, and the molecular mechanisms underlying its pathogenesis and severity are poorly understood. We evaluated mRNA and miRNA in patients with ARDS and elucidated the pathogenesis of ARDS after performing mRNA and miRNA integration analysis.

Methods

In this single-center, prospective, observational clinical study of patients with ARDS, peripheral blood of each patient was collected within 24 hours of admission. Sequencing of mRNA and miRNA was performed using whole blood from the ARDS patients and healthy donors.

Results

Thirty-four ARDS patients were compared with 15 healthy donors. Compared with the healthy donors, 1233 mRNAs and 6 miRNAs were upr

SUBMITTER: Mitsuyama Y 

PROVIDER: S-EPMC10987699 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature