Characterization of the m⁶A regulators' landscape highlights the clinical significance of acute myocardial infarction.

ABSTRACT:

Objective

Acute myocardial infarction (AMI) is a severe cardiovascular disease that threatens human life and health globally. N⁶-methyladenosine (m⁶A) governs the fate of RNAs via m⁶A regulators. Nevertheless, how m⁶A regulators affect AMI remains to be deciphered. To solve this issue, an integrative analysis of m⁶A regulators in AMI was conducted.

Methods

We acquired transcriptome profiles (GSE59867, GSE48060) of peripheral blood samples from AMI patients and healthy controls. Key m⁶A regulators were used for LASSO, and consensus clustering was conducted. Next, the m⁶A score was also computed. Immune cell infiltration, ferroptosis, and oxidative stress were evaluated. In-vitro and in-vivo

SUBMITTER: Chao P 

PROVIDER: S-EPMC10987706 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature