The pharmacokinetics and pharmacodynamics of fentanyl administered via transdermal patch in horses.

ABSTRACT:

Introduction

Understanding the pharmacokinetics and pharmacodynamics of fentanyl in horses is crucial for optimizing pain management strategies in veterinary medicine.

Methods

Six adult horses were enrolled in a randomized crossover design. Treatments included: placebo, two 100 mcg/h patches (LDF), four 100 mcg/h patches (MDF), and six 100 mcg/h patches (HDF). Patches were in place for 72 h. Blood was obtained for fentanyl plasma concentration determination, thermal threshold, mechanical threshold, heart rate, respiratory rate, and rectal temperature were obtained prior patch placement and at multiple time points following patch placement for the following 96 h. Fentanyl plasma concentration was determined using LC-MS/MS. Data were analyzed using a generalized mixed effects

SUBMITTER: Reed RA 

PROVIDER: S-EPMC10987731 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature