Discovery of an independent poor-prognosis subtype associated with tertiary lymphoid structures in breast cancer.

ABSTRACT:

Introduction

Tertiary lymphoid structures (TLSs) are ectopic lymphoid formations that arise in non-lymphoid tissues due to chronic inflammation. The pivotal function of TLSs in regulating tumor invasion and metastasis has been established across several cancers, such as lung cancer, liver cancer, and melanoma, with a positive correlation between increased TLS presence and improved prognosis. Nevertheless, the current research about the clinical significance of TLSs in breast cancer remains limited.

Methods

In our investigation, we discovered TLS-critical genes that may impact the prognosis of breast cancer patients, and categorized breast cancer into three distinct subtypes based on critical gene expression profiles, each exhibiting substantial differences in prognosis (p =

SUBMITTER: Liu R 

PROVIDER: S-EPMC10987760 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature