Assessing of case-cohort design: a case study for breast cancer patients in Xinjiang, China.

ABSTRACT:

Objective

To assess the effectiveness and clinical value of case-cohort design and determine prognostic factors of breast cancer patients in Xinjiang on the basis of case-cohort design.

Methods

The survival data with different sample characteristics were simulated by using Cox proportional risk models. To evaluate the effectiveness for the case-cohort, entire cohort, and simple random sampling design by comparing the mean, coefficient of variation, etc., of covariate parameters. Furthermore, the prognostic factors of breast cancer patients in Xinjiang were determined based on case-cohort sampling designs. The models were comprehensively evaluated by likelihood ratio test, the area under the receiver operating characteristic curve (AUC), and Akaike Information Criterion (AIC)

SUBMITTER: Wu M 

PROVIDER: S-EPMC10987809 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature