The ST2⁺ Treg/amphiregulin axis protects from immune-mediated hepatitis.

ABSTRACT:

Introduction

The alarmin IL-33 has been implicated in the pathology of immune-mediated liver diseases. IL-33 activates regulatory T cells (Tregs) and type 2 innate lymphoid cells (ILC2s) expressing the IL-33 receptor ST2. We have previously shown that endogenous IL-33/ST2 signaling activates ILC2s that aggravate liver injury in murine immune-mediated hepatitis. However, treatment of mice with exogenous IL-33 before induction of hepatitis ameliorated disease severity. Since IL-33 induces expression of amphiregulin (AREG) crucial for Treg function, we investigated the immunoregulatory role of the ST2⁺ Treg/AREG axis in immune-mediated hepatitis.

Methods

C57BL/6, ST2-deficient (Il1rl1^-/-) and Areg^-/- mice received concanavalin A to induce immune

SUBMITTER: Wachtendorf S 

PROVIDER: S-EPMC10987816 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature